Pharmacotherapy is employed to target the individual components of metabolic syndrome: antihypertensive agents (e.g., ACE inhibitors, ARBs and calcium channel blockers) are used to manage hypertension; statins and fibrates are prescribed to correct dyslipidemia by lowering LDL cholesterol and triglycerides while raising HDL cholesterol; and insulin sensitizers, such as metformin and thiazolidinediones, are used to enhance glucose uptake and reduce insulin resistance. Here, INS is linked to Insulin resistance.