Nadeem et al. synthesized and evaluated indole core-containing 2-arylidine derivatives of thiazolopyrimidine as multitarget inhibitors for cholinesterases AChE and BChE as well as monoamine oxidase isoforms (MAO-A and MAO-B) [175], aiming to treat Alzheimer’s disease. This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.