BIRC5 and cancer: These siRNA-target genes are mainly those that promote cell differentiation and proliferation and inhibit apoptosis, which are overexpressed in cancer cells, such as Bcl-2 [24], survivin [25], epidermal growth factor receptor (EGFR) [26], Janus kinase 1 (JAK1) [27], and polo-like kinase 1 (PLK1) [28].