Hoshiyama et al. achieved the inhibition of tumor growth signaling through aptamer-mediated cleavage using a bispecific aptamer that simultaneously targets fibroblast growth factor receptor 1 (FGFR1) and thrombin, a protease that selectively cleaves Arg–Gly bonds (Figure 5C) [139]. Here, FGFR1 is linked to neoplasm.