For instance, TRPV1 is highly expressed in various aggressive tumors, while blocking TRPV1 can inhibit hyperthermia-induced calcium influx, which in turn suppresses heat shock protein (HSP70) overexpression by preventing HSF1 from translocating to the nucleus [35], suggesting that TRPV1 plays a critical role in the cellular stress response within tumor environments. Here, TRPV1 is linked to neoplasm.