This article, by summarizing the mechanism of action of PCA in cognitive impairment, discovers that PCA can function through multiple pathways such as regulating the expression of neuroprotective factors, inhibiting apoptosis, promoting the autophagy-lysosome pathway, suppressing oxidative stress damage, inhibiting inflammatory responses, ameliorating synaptic plasticity dysfunction, inhibiting Aβ deposition and reducing APP hydrolysis, improving the cholinergic system, suppressing excitotoxicity of neuronal cells, and inhibiting ferroptosis. This evidence concerns the gene APP and Cognitive impairment.