The abovementioned results indicate that, in addition to their crucial roles as agents of cell cycle arrest and apoptosis induction, the intriguing discovery about the interactions between the structures of chromenopyrimidines and the Bcl-2 and Mcl-1 proteins/antagonist highlights the promising effect of 3a and 4a as anti-breast cancer agents. The gene discussed is BCL2; the disease is breast carcinoma.