In particular, circCDR1as was proven to suppress osteogenic differentiation of bone marrow mesenchymal stem cells in steroid-induced osteonecrosis of the femoral head by regulating the miR-7-5p/WNT5B axis, and its expression in plasma and local tissues were closely associated with the disease severity in patients with osteonecrosis of the femoral head [14, 15]. The gene discussed is WNT5B; the disease is osteonecrosis.