Based on the bulk RNA-seq data analysis, 13 DE-NRGs were screened out between MDS and health controls, including TNFRSF1A, PPID, PLA2G4A, MLKL, IL1A, TNFSF10, FAS, JAK2, STAT1, STAT3, IRF9, USP21, BAX. Here, USP21 is linked to myelodysplastic syndrome.