Similarly, CRC-derived miR-21-5p and miR-200a synergistically promote M2-like macrophage polarization and PD-L1 expression through the regulation of the PTEN/AKT and SCOS1/STAT1 pathways, leading to decreased CD8 + T cell activity and enhanced tumor growth [32]. The gene discussed is AKT1; the disease is colorectal carcinoma.