AKT1 and glioblastoma: As expected, when GBM#P3 co-cultured with HMC3 with si-NC, si-PHLPP2#1 or si-PHLPP2#2, knockdown PHLPP2 significantly promoted the proliferation and migration of GBM#P3 (Fig. 5N, O, Figure S7J, K) These results revealed that miR-25-3p activated PI3K-AKT pathway by silencing PHLPP2.