In this study, we uncovered miR-25-3p, originating from hypoxic glioma cells, is transported to macrophages through exosomes, serving as a mediator that facilitate M2 polarization in macrophages via the miR-25-3p/PHLPP2/PI3K-AKT-mTOR signaling pathway. The gene discussed is PHLPP2; the disease is central nervous system cancer.