Hormetic nutrients and their metabolites at low doses are considered chemopreventive agents, upregulating the Nrf2 pathway and downstream phase II detoxification vitagenes to induce cytoprotection, and can be used as useful dietary supplements in cancer chemoprevention to suppress oxidative stress and inflammation and avert proliferation in humans with genetic predisposition to develop cancer [167–169]. This evidence concerns the gene NFE2L2 and cancer.