The median plasma OPN level in the Swedish study cohort with malaria was 209 ng/mL (IQR: 105 – 264 ng/mL), which was significantly higher compared to the median plasma OPN level of the Swedish control group consisting of healthy volunteers (100 ng/mL, IQR: 75 – 111; p = 0.0047) (Fig. 1). The gene discussed is SPP1; the disease is malaria.