Esteller reported that transcriptional silencing of RBP1 was associated with CpG island promoter hypermethylation in HN12(head and neck cancer cell lian), Shigeru Tsunoda et al. found that RBP1 showed more frequent methylation in the tumor than the matched proximal resection margin of uninvolved esophagus [12, 49]. Here, RBP1 is linked to malignant tumor of neck.