A further search of Open-Target provided evidence supporting drug targets for six proteins (ADH1B, ALDH5A1, APOE, CFB, FN1, ALDH2), with three having approved drugs that target conditions such as age-related macular degeneration (ADH1B), eye disease (FN1), parasitic infection or treatment of alcohol addiction (ALDH2), and bipolar disorder or epilepsy (ALDH5A1; Supplementary Table 7). This evidence concerns the gene APOE and eye disorder.