Among these 10 proteins (posterior probability H4 > 0.6), independent 2SMR analyses, using CKB cis-pQTLs and published GWAS summary statistics, showed evidence of causal associations with stroke (ALDH2), IHD (SERPINF2), T2D (natural cytotoxicity triggering receptor 3 ligand 1 [NCR3LG1], ALDH2, ITIH4, apolipoprotein E [APOE], ADH1B), low-density lipoprotein cholesterol (LDL-C; APOE, ALDH2, SERPINF2, FN1, ITIH4) and systolic blood pressure (SBP; FN1). The gene discussed is APOE; the disease is type 2 diabetes mellitus.