Of the 193 proteins significantly associated (Bonferroni < 0.05) with adiposity in genetic analyses, three proteins (LPL, PON3 and gamma-synuclein [SNCG]) were also associated with T2D in a two-sample MR (2SMR) analyses using CKB cis-protein quantitative trait locus (cis-pQTLs) in Asian Genetic Epidemiology Network (AGEN). This evidence concerns the gene SNCG and type 2 diabetes mellitus.