Moreover, a recent study developed a new version of G47∆ expressing IL-2 (G47Δ-mIL2), which can significantly prolong the survival of different GBM mouse models associated with increased intratumoral CD8+ T cells, suggesting that G47Δ-mIL2 may represent a new direction of HSV treatment for GBM patients [132], but further clinical trials are needed. Here, CD8A is linked to glioblastoma.