This is partly due to their association with inborn errors of the immune system, thrombocytopenia, and/or predisposition to leukaemia (IKZF1 and IKZF3) and to somatic defects that are frequently occurring in haematological malignancies (IKZF1 and IKZF2) (Kuehn et al. 2016; Lentaigne et al. 2019; Park et al. 2019; Shahin et al. 2022; Yamashita et al. 2021). The gene discussed is IKZF1; the disease is leukemia.