This includes the decision to exclude genes linked to disease in OMIM in the AR group, despite the possibility that variants in the same genes can lead to different disorders, as shown here for IKZF2. The main reason for applying the stringent strategy for variant prioritization and thereby reduction of candidate variants is the effort needed for follow-up in families to confirm co-segregation of variants with HL. The gene discussed is IKZF2; the disease is Hodgkins lymphoma.