YWHAE and Miyoshi myopathy: Proteasome inhibitors are a cornerstone of MM treatment, yet resistance remains a challenge.201,202 The expression of 14-3-3δ not only serves as a prognostic marker but also influences proteasome assembly, impacting MM cell viability.10,203 The sensitivity of MM cells to proteasome inhibitors appears to be modulated by 14-3-3ε, with knockdown studies revealing altered responses to treatment.204 These findings uncover the importance of elucidating the roles and mechanisms of 14-3-3 isoforms in MM to inform the development of targeted therapeutics.