YWHAE and cancer: 14-3-3ε modulates the TNF-α-induced activation of NF-κB, a key transcription factor in inflammation and immune responses.26 By dynamically interacting with components of the MAPK signal module, such as TAK1 and PPM1B, 14-3-3ε selectively influences the time course-dependent NF-κB activity.92,93 This interaction is crucial for the fine-tuning of inflammatory responses, preventing excessive cytokine production that can lead to pathologies like cancer.