Studies demonstrate that OA patients with diabetes and cardiovascular disease experience accelerated cartilage degeneration.152 In a diabetic cardiomyopathy model, Ask1 activation in 14-3-3η heart-specific knockout mice significantly impaired cardiac function.153 Whether 14-3-3 involvement in diabetic cardiomyopathy further affects OA requires experimental evidence. Here, MAP3K5 is linked to diabetic cardiomyopathy.