14-3-3ζ isoform can promote cancer cell survival by binding to the p85α regulatory subunit of PI3K and activating Akt.78,79 Downstream of Akt, 14-3-3 proteins bind to and sequester FOXO transcription factors in the cytoplasm, inhibiting their pro-apoptotic and cell cycle arrest functions.77,80. Here, AKT1 is linked to cancer.