Studies have shown that both primary and metastatic OS tissues show positivity for Glucose transporter protein-1 (Glut-1), a key protein in glucose metabolism, suggesting increased glucose uptake in OS.177 14-3-3 regulates glucose uptake by interacting with AKT-AS160 phosphorylation, affecting Glut-1.178 Regarding obesity and OS, the fat mass and obesity-associated protein induces OS migration and invasion.179 However, as with OA, direct evidence for 14-3-3 involvement in OS development through the regulation of obesity or blood glucose is lacking. The gene discussed is SLC2A1; the disease is obesity due to melanocortin 4 receptor deficiency.