YWHAQ and neoplasm: The 14-3-3 proteins are instrumental in the regulation of the Hippo signaling pathway, a critical determinant of cellular proliferation and apoptosis, which in turn influences organ size and tumor suppression.89 Within the canonical Hippo pathway, a kinase cascade phosphorylates the transcriptional coactivators YAP and TAZ at specific sites that are recognized by 14-3-3 proteins.