YWHAE and rheumatoid arthritis: This reduction in PGRN’s efficacy was particularly pronounced in the context of inflammatory arthritis, where PGRN’s inflammation-suppressing effects were compromised in mice with a myeloid-specific deficiency in 14-3-3ε.26 These insights collectively point to the TNFR2/14-3-3ε signaling axis as a crucial modulator of macrophage plasticity and reveal a promising therapeutic target for immune modulation in RA.