POSTN and myocardial infarction: In molecular mechanisms, mechanosensitive YAP has been implicated in exacerbating inflammation through the regulation of M1/M2 macrophage polarization.66 Additionally, periostin has been shown to regulate M2 macrophage polarization in myocardial infarction and cancer.67 We demonstrated that periostin regulated macrophage polarization in the skeletal system.