Deubiquitinase ubiquitin-specific protease 7 (USP7), also known as herpesvirus-associated ubiquitin-specific protease (HAUSP), has been regarded as an important regulator of tumorigenesis in several cancers [21], but its potential roles in ccRCC and the underlying mechanisms have long been mysterious. This evidence concerns the gene USP7 and nonpapillary renal cell carcinoma.