In this study, we compared DUB family protein expression in ccRCC and the adjacent normal tissues using two published proteomics data [26, 27], and revealed that five DUBs (USP5, USP7, USP10, USP47, and OTUD6B) were commonly upregulated in ccRCCs (Fig. 1a). This evidence concerns the gene ZUP1 and nonpapillary renal cell carcinoma.