We next performed in silico analysis of the correlation between USP7 and 795 transcription factors in 534 ccRCC samples, and the top 50 transcription factors positively correlated with USP7 were shown, including two members of the far upstream element binding protein (FUBP) family, FUBP1 and FUBP3, which were reported to have similar properties of DNA sequence binding and regulating gene expression (Fig. 1f, Supplementary Fig. S1a) [28]. The gene discussed is USP7; the disease is nonpapillary renal cell carcinoma.