Through a screen of deubiquitinase complementary DNA (cDNA) library that contains 60 deubiquitinases without USP7, Qing Zhang’s group identified USP37 as a HIF2α binding partner, which can deubiquitinate and stabilize HIF2α in ccRCC [43]. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.