However, RNA sequencing in our study did not reveal a primary role of oxidative stress-related genes and available antioxidant therapies have failed to improve doxorubicin-induced cardiomyopathy.3 Second, doxorubicin may induce various forms of programmed cell death apart from apoptosis, such as pyroptosis, necroptosis and ferroptosis.61–63 Thus, further research is needed to explore the impact of ADAM17 on other forms of cell death in doxorubicin-induced cardiomyopathy. Here, ADAM17 is linked to cardiomyopathy.