Recent studies by our team demonstrated that ADAM17 knockdown affected autophagy through regulating the AMPK signaling pathway, thereby alleviating cardiomyocyte apoptosis and improving diabetic cardiomyopathy.14 However, the relationship between cardiomyocyte ADAM17 and doxorubicin-induced cardiomyopathy is unclear. The gene discussed is ADAM17; the disease is cardiomyopathy.