ADAM17 and cardiomyopathy: However, the protein and mRNA expression levels of ADAM17 were dramatically decreased in the siC/EBPβ + DOX group versus the siNC + DOX group (Supplementary Fig. 7f–j), suggesting that C/EBPβ might be an upstream mediator of ADAM17 upregulation in mice with doxorubicin-induced cardiomyopathy.