Recent studies by our team demonstrated that ADAM17 knockdown affected autophagy through regulating the AMPK signaling pathway, thereby alleviating cardiomyocyte apoptosis and improving diabetic cardiomyopathy.14 However, the relationship between cardiomyocyte ADAM17 and doxorubicin-induced cardiomyopathy is unclear. This evidence concerns the gene ADAM17 and diabetic cardiomyopathy.