In children, SYNGAP1 haploinsufficiency causes a developmental epileptic encephalopathy characterized by moderate to severe intellectual deficiency, generalized epilepsy (Hamdan et al., 2009; Rauch et al., 2012; Berryer et al., 2013; Carvill et al., 2013; von Stulpnagel et al., 2015; Mignot et al., 2016), and behavioral anomalies, including autism spectrum disorder and sensory processing impairment (Hamdan et al., 2011; Berryer et al., 2013; Michaelson et al., 2018; Carreno-Munoz et al., 2022; Lyons-Warren et al., 2022; Wright et al., 2022). The gene discussed is SYNGAP1; the disease is autism spectrum disorder.