Impaired social behavior was observed in mouse models carrying Nkx2.1 or PV interneuron–specific haploinsufficiency of tuberous sclerosis 1 (TSc1; Amegandjin et al., 2021), which in humans causes tuberous sclerosis, a disorder associated with seizures, intellectual disability, and autism. Here, NKX2-1 is linked to tuberous sclerosis.