Syngap1/SYNGAP1 haploinsufficiency is associated with epileptic encephalopathy in humans and altered ictal activity and threshold to seizure induction in mice (Clement et al., 2012; Berryer et al., 2013; Vlaskamp et al., 2019; Carreno-Munoz et al., 2022). This evidence concerns the gene SYNGAP1 and Epileptic encephalopathy.