INS and diabetes mellitus: Taken together, the intense simplified strategy provides an effective, safe, and affordable approach for patients with newly diagnosed type 2 diabetes and significant hyperglycaemia, avoiding the disadvantages of complex regimens.32, 33 This finding is supported by an observational study from Shambo and colleagues, which showed long term glycaemic control and reduced need for anti-diabetes agents after early insulin initiation in type 2 diabetes.34