In addition, the suppression of bone marrow-derived macrophage function occurred through the inhibition of ETA by downregulating the expression of IL-6, a multifunctional cytokine that has pro-inflammatory effects in PAH, as well as by downregulating the expression level of the monocyte chemoattractant protein-1 (MCP1). This evidence concerns the gene CCL2 and pulmonary arterial hypertension.