PPARGC1A and pulmonary arterial hypertension: In terms of anti-inflammatory stress sensors, it was observed that peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) overexpression in PAECs significantly blocked EndoMT, indicating that PGC-1α inhibition may protect against PAH development by preserving lung EC function and reducing pulmonary vascular remodeling (31).