We detected 2,854 genes (8,511 transcripts) with recurrent aDMRs at their promoters, including the cancer genes RET and CDKN2A. TF enrichment analysis of these genes demonstrated significant enrichment for PRC1 and PRC2 complex protein subunits (adjusted p < 0.05 from Enrichr; Figure S11C). The gene discussed is TF; the disease is cancer.