Three of the integration events were associated with elevated expression (≥85th percentile2; Figure S6B) of neighboring cancer genes, including P3H2, MYC, CDKN2A, and CDKN2B. POG109 exhibited allele-specific expression (ASE) of PVT1, the gene it overlapped, with higher expression from the haplotype containing the integration. The gene discussed is CDKN2A; the disease is cancer.