Consistentwith the in vitro results, Dox and cGAMPnps (Dox-cGAMPnp@Gel) synergisticallyincreased STING activation in tumors and tumor draining lymph nodes(TDLN), as indicated by the increased expression of type I IFN-relatedgenes (Ifna1, Ifnb1, Tnf, and Cxcl10) compared with their expression upontreatment with cGAMPnps (cGAMPnp@Gel) or Dox (Dox@Gel) alone (Figure 5H). Here, TNF is linked to neoplasm.