Consequently, the hydrogel loaded with both Doxand cGAMPnps (Dox-cGAMPnp@Gel) substantially increased tumor perfusion(Hoechst 33342+) (Figure 6D), the proportions and activation of DCs and cytotoxicT cells within tumors and TDLNs (Figure 6D,E), and the proportions of CD62L+CD44+ central memory CD8 T cells in spleens (Figure 6F), when comparedto no treatment control, the empty Gel, cGAMPnp@Gel, Dox@Gel, or freedrugs, leading to the complete suppression of tumor growth and distallung metastasis in the orthotopic 4T1 breast tumor model (Figure 6G,H). The gene discussed is CD44; the disease is breast neoplasm.