Notably, GBM, HCC, and PDAC, often referredto as “immunologically cold” due to their sparse tumor-infiltratinglymphocytes and excessive immunosuppressive cells, have shown potentefficacy with this treatment.36−39 This vaccination approach led to STING-induced tumorvascular normalization and a significant increase in DC activationand effector CD8+ T cells in both tumors and associatedlymph nodes, indicating robust antitumor immunity. The gene discussed is CD8A; the disease is neoplasm.