As aresult, when either aPD1-Dox-cGAMPnp@Gel or OX40L-Dox-cGAMPnp@Gelwas administered, tumor growth was significantly slower than thatinstigated by administering hydrogel formulations comprising the anti-PD-1antibody alone, OX40L alone, or Dox-cGAMPnp@Gel (Figure 7F). The gene discussed is TNFSF4; the disease is neoplasm.