Another possible mechanismis the activation of other inflammatory pathways, such as the Toll-likereceptor, RIG-I, STAT, and intracellular calcium regulation pathways,which may enhance STING expression and activation or downstream effectors.These findings provide a foundation for future studies to explorehow DAMPs and STING agonists orchestrate a coordinated immune response,suggesting that combining STING agonists with ICD-inducing agentscould be a promising cancer immunotherapy strategy. Here, RIGI is linked to cancer.