CD8A and neoplasm: Furthermore,the gel could provide structural support for immune cells, improvingtheir infiltration and retention within the tumor.57 When administered into the tumor bed, this in situ gelvaccine significantly induced the STING-driven vascular normalization,reprogrammed the immunosuppressive TME and boosted the quantity andactivation of cytotoxic CD3+CD8+ T cells intumors, TDLNs and premetastatic lungs.