Our findings illuminatethe role of SF hydrogels as effective vehiclesfor cancer immunotherapy, owing to their ability for sustained, controlledrelease of diverse therapeutics.38 We showedthe enhanced therapeutic potential of an in situ gel vaccine encapsulatingan ICD inducer (Dox), a nanoscale STING agonist (cGAMPnps), and immunomodulators(anti-PD-1 antibody or OX40L). Here, TNFSF4 is linked to cancer.