Moreover, cGAMP delivered via cGAMPnp@Gel demonstrateda superior intracellular uptake in the tumor tissue compared to freecGAMP (Figure 5F),primarily taken up by CD45+CD11c+ DCs, CD45+F4/80+ macrophages, and CD45+CD11b+ monocytes (Figure 5G). Here, ITGAM is linked to neoplasm.