In the present study, we found that LRP1 was frequently under‐expressed in both human HCC tissues and proliferating HCC cell lines, which was closely associated with high‐grade HCC and poor prognosis in HCC patients, in contrast to its effect on glioblastoma.[5d] Moreover, LRP1 deficiency enhanced HCC cell proliferation, migration, and survival, thus promoting HCC cell xenograft tumor formation. This evidence concerns the gene LRP1 and neoplasm.