LRP1 expression is dysregulated in multiple tumors, including prostate, breast, colon, thyroid, and endometrial cancers, implicating a functional role for LRP1 in cancer susceptibility and progression.[7, 15] Recently, LRP1 was reported to interact with apoE to promote colorectal cancer (CRC) migration and invasion.[16] However, Rong et al. Here, APOE is linked to colorectal cancer.