NFKB1 and cancer: Notably, UFL1 has been reported to function as a negative regulator of NF‐κB signaling, inhibit NF‐κB activity, and prevent LPS‐induced ER stress and apoptosis.[29] Although aberrant UFM1 modification has been implicated in various types of human cancers, its biological role of UFL1 in tumorigeneses remains to be investigated.[30] In view of the diverse functions of UFL1, further studies are needed to elucidate the detailed mechanism by which UFL1 coordinates with LRP1 to regulate OGA turnover and the downstream activation of NF‐κB.