Since the elevated expression of TREM2 was observed in monocytes/macrophages during sepsis (Figure 1), we next generated TREM2 conditional knockout mice (TREM2fl/flLyz2Cre), in which TREM2 was specifically deleted in macrophages, to explore whether TREM2 exerted functions in sepsis via macrophages. The gene discussed is TREM2; the disease is Sepsis.