Although Adn-Lpin1–/– mice exhibited transcriptional profiles consistent with the development of MASH, there were no significant changes in plasma alanine transaminase (ALT) or aspartate aminotransferase (AST) levels, surrogate markers of liver damage, and histological scoring of H&E liver sections did not reveal any significant changes (Supplemental Figure 9, B and C). Here, GPT is linked to metabolic dysfunction-associated steatohepatitis.