We compared LPIN1 gene expression in subcutaneous abdominal adipose tissue from people who were metabolically healthy and lean (MHL), metabolically healthy with obesity (MHO), and metabolically unhealthy with obesity (MUO), stratified based on body mass index (BMI), glucose tolerance, hemoglobin A1c, and intrahepatic triglyceride (IHTG) content assessed by MRI (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI169722DS1) (11). This evidence concerns the gene LPIN1 and obesity due to melanocortin 4 receptor deficiency.