NLRP3 and Sepsis: Contrastingly, C12 AMs emerged as a marked population post-sepsis (0.1% in WT Sham versus 43.7% in WT PA), characterized by a distinct proinflammatory signature with elevated expression of the inflammasome Nlrp3 gene, alongside increased levels of proinflammatory cytokine and chemokine genes (Figure 3E).