In the exploration of the effects of Padi2 and Padi4 DKO on ALI and survival in a PA pneumonia–induced sepsis model, we first constructed the model and validated the knockout efficiency (Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.181686DS1). This evidence concerns the gene PADI4 and Sepsis.