Labeling of SPAK, a kinase downstream of lysine-deficient protein kinase 1 (WNK1) and WNK4 and upstream of NCC (32–34), demonstrated increased intensity and abundance of punctuated condensates resembling hypokalemia-related WNK+ bodies in the index patient compared with control samples (Figure 8) (35). The gene discussed is WNK4; the disease is Hypokalemia.