TARDBP and amyotrophic lateral sclerosis: Investigation of hyperexcitability and excitotoxicity in animal models, notably the SOD1G93A transgenic mouse, and models based on TDP-43 variants or forced mislocalisation, has been a focal point in ALS research (e.g. (Pieri et al. 2003; Dyer et al. 2023; Fogarty et al. 2016).