In the current study, we also observed that FVIII levels showed no to weak association with the incidence of type 2 diabetes in the total population while we found that the HR (95% CI) was 1.99 (0.95–4.17) in women and 0.97 (0.51–1.83) in men when comparing the highest quartile to the lowest quartile. The gene discussed is F8; the disease is type 2 diabetes mellitus.