NES and chronic kidney disease: Furthermore, the increased ECM deposition is in line with proteomics data which also showed upregulation of ECM proteins like Fibrillin 1 (FN1) and the intermediate filament protein Nestin (NES), while FBN1, LAMA2, LAMB2 and LAMC1 were downregulated (red in string plot) in CKD swine (Fig. 2 a,b).