We have recently shown that the disrupted epithelial cell differentiation and enterocyte maturation in the MYO5B-deficient intestine is likely another pathology that underlies the malabsorption symptoms of MVID (12, 13), in addition to MYO5B-mediated transporter trafficking defects investigated in differentiated cells (44, 45). This evidence concerns the gene MYO5B and microvillus inclusion disease.