MYO5B and microvillus inclusion disease: Here, we show that functional MYO5B loss impairs mitochondria and cellular metabolic pathways, which may affect epithelial cell development, and that the synthetic LPAR5 agonist Compound-1 partially rescued enterocyte maturation and tuft cell differentiation in two MVID mouse strains in vivo and in Navajo MVID patient-modeled pig enteroids.