MYO5B and microvillus inclusion disease: In the MYO5BΔIEC mouse jejunum, both villus and crypt cells showed immature and disorganized microvilli and the accumulation of abnormal vesicles in the subapical space (Fig. 1A, yellow arrows in right panel), similar to those of the MVID patient-modeled mice, MYO5B(G519R) (7).