Compound-1 treatment improved NHE3 localization to the brush border and significantly reduced the colocalization of NHE3 and LAMP1 by ∼50% (Fig. 5E), indicating that LPAR5 activation ameliorates brush border maturation in both MVID mouse models: MYO5B-deficient mice and the mice with a point mutation at MYO5B(G519R). Here, LPAR5 is linked to microvillus inclusion disease.