MYO5B and microvillus inclusion disease: To understand better the pathophysiology of the intestine with inactivated MYO5B, we have established several experimental models of MVID: MYO5B-deficient mouse strains (9), MVID patient-modeled mice with a compound heterozygous mutation at MYO5B(G519R) (7), and a genetically engineered pig model with a homozygous MYO5B(P663L) mutation that is homologous with the MYO5B(P660L) mutation identified in Navajo MVID patients (10).