Other studies have shown that TGFBR3 plays a tumor-suppressive role in cervical cancer (18), head and neck cancer (19), lung cancer (20), breast cancer (21), etc. Currently, only a few studies have focused on the role of TGFBR3 in thyroid cancer, which merely identified TGFBR3 as a diagnostic or prognostic biomarker (22, 23). The gene discussed is TGFBR3; the disease is thyroid cancer.