ATP8B1 and infection: In the absence of BREXInd5, and in line with our qPCR results, the number of reads mapping to the ICP1 ΔorbA genome was robust at 10 minutes post-infection, whereas, in the presence of BREXInd5, the number of reads mapping to the ICP1 ΔorbA genome appeared the same at both time points, indicating that the ICP1 ΔorbA did not replicate (Fig. 1C).