TAMs respond to hypoxic conditions within tumor tissue by secreting various factors, including VEGFs, basic fibroblast growth factor (bFGF), thymidine phosphorylase [83], and multiple matrix metalloproteinases (MMPs), such as MMP-2, MMP-7, MMP-9, and MMP-12 [148]. This evidence concerns the gene FGF2 and neoplasm.