NPC2 and cancer: Especially five cancer-gene pairs were identified: (1) for pancreatic adenocarcinoma PACA-MAN2B1, PACA-GALNS, PACA-GUSB (2) for cutaneous melanoma SKCM–NPC2, (3) for chronic myeloid disorder CMDI–SGSH, (where PACA is an abbreviation for pancreatic adenocarcinoma, MAN2B1—the gene for alfa-mannosidosis, GALNS—the gene for mucopolysaccharidosis type IV A, GUSB—the gene for mucopolysaccharidosis type VII, SKCM—for cutaneous melanoma, NPC2—gene for Niemann-Pick disease type C, CMDI—for chronic myeloid disorder, SGSH—gene for mucopolysaccharidosis type III A) [78].