Importantly, kisspeptin treatment of DIAMOND mice fed a high-fat ‘Western’ diet (HFD) and sugar water exhibited a significant reduction in several inflammatory and profibrogenic markers [13], including transforming growth factor β1 (TGFβ1), a critical mediator of hepatic fibrosis [19,20] and decreased hepatic hydroxyproline levels (indicative of collagen content) [13]. The gene discussed is KISS1; the disease is Hepatic fibrosis.