Additionally, using validated antibodies [13,29,30], immunohistochemical analysis of endogenous KISS1R in human livers from MASH patients with fibrosis revealed that KISS1R is robustly expressed in hepatic stellate cells (red) and colocalizes (yellow, overlay) with desmin (green), an intermediate filament marker of hepatic stellate cells [31] (Figure 4G). Here, DES is linked to metabolic dysfunction-associated steatohepatitis.