NFE2L2 and neoplasm: NRF2 increased the proliferation of tumor cells by increasing the expression of glycolytic enzymes including glucose-6-phosphate dehydrogenase, phosphoglucomutase dehydrogenase, transketolase and trans-aldolase [64], which control genes involved in fatty acid-lipid metabolism [65], growth-associated genes [66], and cell cycle regulators [67].