STX17 and metabolic dysfunction-associated steatotic liver disease: From a therapeutic perspective, in addition to reverting the low rates of homocysteine methylation and transmethylation of methionine in NAFLD [171], vitamin B12 and folate dietary supplementation could restore homocysteine metabolism through the activation of Syntaxin 17 (STX17)-dependent autophagy, increasing β-oxidation of FAs and consequently decreasing inflammation and fibrosis [172] (Table 4).