Furthermore, α- and γ-tocopherol can decrease hepatic steatosis, modulating the expression of hepatic retinaldehyde dehydrogenases (Raldh1, Raldh2, and Raldh3), which govern the ubiquitous metabolism of retinol and the lipogenic factors SREBP-1c, which controls the synthesis of lipids from glucose in the liver [235]. This evidence concerns the gene SREBF1 and fatty liver disease.