In prostate cancer, numerous splice variants play significant roles in the development of the disease, e.g., VEGFA, KLF6, BCL2L1, ERG, SH3GLB1, FGFR2, CCND1, PCSK6, CLK1, PIK3CD, ST6GalNAc1, 17βHSD4, BCL-X, ERG, and AR [55,56,57,66]. This evidence concerns the gene ERG and Familial prostate cancer.