The FLOT1 highly expresses in prostate tissue and its role reflects the cellular function of cytoskeleton, involving cell proliferation [11,12,13,14,15,16,17,18], cell migration and tumor progression [12,19,20], cell invasion [16], tumorigenesis [13,17], angiogenesis [76], epithelial-mesenchymal transition [17], cell-cycle modulation [14,17], and treatment resistance [11,19,21]. The gene discussed is FLOT1; the disease is neoplasm.