Comparing the UHCs above the 65 years of age versus AKI patients above 65 years, there is a sub-group of upregulated SASP proteins in AKI such as MMP3, IL16, TNFRSF10C, CCL23, GDF15, TNFR1 and 2, and UPAR (p < 0.01). The gene discussed is IL16; the disease is acute kidney injury.