SIRT1 and Parkinson disease: The effects of autophagy and resveratrol in PD were demonstrated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of the disease, where LC3 promoted autophagic degradation of α-synuclein via the activation of the Sirt1 pathway (Figure 2) [116].