APP and Alzheimer disease: In the Drosophila model that overexpresses the amyloid precursor protein (APP) for a similar AD phenotype, resveratrol treatment showed improvements in sleep and memory that were dependent on the ortholog Sir2, a sirtuin ortholog that in turn stimulates autophagy by activating HSP70 and ATG4, also interacting to LC3 and p62 [111,112].