Noteworthy is the addition of the established clinical prognostic factors of cell or origin and MYC/BCL2 double expression to NCCN‐IPI did not show significant difference in C‐index for both time to recurrence or death; these findings indicate that stromal FOXC1 and tumor pERK1‐2 expression have stronger association with the tumor biology than established prognostic factors. The gene discussed is FOXC1; the disease is neoplasm.