By classical statistics, that is, Harrell's C‐index, the single addition of stromal FOXC1 or tumor pERK1‐2 to NCCN‐IPI improved the C‐index for the prediction of time to recurrence and death compared with NCCN‐IPI alone, although only tumor pERK1‐2 reached statistical significance in prediction of time to death (0.798 vs. 0.764, p = 0.038, Table 3). The gene discussed is FOXC1; the disease is neoplasm.