TP53 and neoplasm: TAp73-specific antibodies are available that have been appropriately characterized (42), but most p73 antibodies are poorly characterized and often show cross-reaction with p63 and/or p53, or even non-specific binding to proteins outside the family (40,42). For example, although the mouse monoclonal antibody to ΔNp73 38C674.2 (also known as IMG-313A) has been widely used, it recognizes a non-specific protein band in Western blotting (42) and shows widespread nuclear and cytoplasmic staining in tumours (133,137).