In this way, the mutation load in healthy tissues like the germline might eventually prove useful for predicting the severity of cancer risk likely to be associated with different pathogenic MUTYH genotypes, allowing clinicians to use whole-genome sequencing to discern whether a family or an individual with a suspicious DNA repair variant is accumulating mutations in normal tissues faster than expected and might be at elevated risk of acquiring a mutation that transforms normal tissue into cancer. The gene discussed is MUTYH; the disease is cancer.