These differences in results may be explained by the distribution of specific types of irAEs as some studies have shown distinct cytokine associations with organ-specific irAEs, such as IL-6 with colitis; IL-17 with colitis, thyroiditis, and pneumonitis; and IL-1β, IL-2, and GM-CSF with thyroid irAEs (11, 66–68). This evidence concerns the gene IL1B and thyroid gland disorder.