In cohorts comprising primarily lung cancers, high baseline and upregulation of IL-10 after ICI treatment, lower baseline levels of various chemokines (CXCL9, CXCL10, CXCL11, and CXCL19), increases in CXCL9 and CXCL10 after ICI exposure, and increased TNF were associated with the development of irAEs (10, 12, 65). This evidence concerns the gene CXCL9 and lung cancer.