IL6 and neoplasm: Among the 6 cytokines associated with grade ≥ 2 irAEs, higher early fold change in IL-6 was associated with worse tumor responses (Figure 5, D and E; P = 0.048), while the other 3 cytokines were not associated with tumor responses by RECIST 1.1 (Figure 5, D and E and Supplemental Table 9).