This observed difference was driven primarily by endocrine (n = 7) and other irAEs (n = 11) for IL-5; dermatologic (n = 5), enterocolitis (n = 6), and endocrine irAEs for IL-6; and pneumonitis (n = 5) for TNF-α (Figure 4D; P < 0.05). Here, IL6 is linked to enterocolitis.