Investigation into the role of cytokines in cancer is often complicated by the fact that their role seems in many cases to be tumor and context dependent; the correlation between IL-6 and outcomes in the spectrum of malignancies represented in Kao et al. (4) is, therefore, particularly notable and suggests that IL-6 blockade may be relevant to improving responses and decreasing toxicity in other solid tumors treated with ICI. This evidence concerns the gene IL6 and neoplasm.