KDM5B, however, has been identified as a tumor suppressor in MLLr AML (109) and NUP98r AML (69), and KDM5C has also recently identified as a tumor suppressor, with a particularly strong association between KDM5C expression and long-term progression-free survival in female patients with AML (110). This evidence concerns the gene KDM5B and acute myeloid leukemia.