A recent study reporting MLL1 and menin as molecular dependencies in NUP98-rearranged AML demonstrated that the menin inhibitor VTP50469 (closely related to revumenib) extended survival in patient-derived xenograft models of NUP98-KDM5A and NUP98-NSD1 AML (68). Here, KDM5A is linked to acute myeloid leukemia.