NSD1 and rhabdoid tumor: However, another study recently demonstrated that H3K36me2 deposited by the methyltransferase NSD1 is required for transcriptional activation upon EZH2 inhibition, with NSD1 loss conferring resistance to EZH2 inhibition in SMARCB1-deficient rhabdoid tumor cell lines that could be rescued by further inhibition of the H3K36 demethylase KDM2A (27).