Remarkably, entirely somatic homozygosity or, more rarely, somatic heterozygosity for CBL UbLOF variants underlies a substantial proportion of other types of myeloid leukemia (42), including approximately 10% of cases of chronic monomyelocytic leukemia (CMML) and approximately 9% of cases of acute myeloid leukemia (AML) (32, 43). The gene discussed is CBL; the disease is myeloid leukemia.